About PLIP

PLIP (Protein Ligand Interaction Profiler) allows you to easily identify non-covalent interactions between biological macromolecules and their ligands and provides you with atom-level information on binding characteristics as well as publication-ready visualizations and parsable output files. While it was originally developed for analyzing only interactions with Proteins (and this history is still reflected in the name) today DNA and RNA structures can serve as receptors too. For a short tutorial and detailed information see the help section.

The PLIP web tool is based on the PLIP command line tool and offers a graphical interface for a quick and comfortable analysis of few structures. For batch processings we recommend to download the command-line tool from GitHub which you can also integrate into your analysis pipeline. It also supports some additional features not available through the webtool (yet).

How to Cite Us

Using PLIP in your work? Please cite:

Adasme, M. F. et al. PLIP 2021: expanding the scope of the protein–ligand interaction profiler to DNA and RNA. Nucl. Acids Res. (2021). doi: 10.1093/nar/gkab294

PLIP was first published in:

Salentin,S. et al. PLIP: fully automated protein-ligand interaction profiler. Nucl. Acids Res. (1 July 2015) 43 (W1): W443-W447. doi: 10.1093/nar/gkv315

Get the paper


PLIP web is brought to you by the Michael Schroeder group at the Biotechnology Center TU Dresden (BIOTEC)

If you have any questions or recommendations please contact Michael Schroeder.

Current PLIP Status

PLIP web is currently running version 2.2.0 of the PLIP command line tool.

External Databases

Since September 2015, the PLIP web service uses the BioLiP database to mark ligands as biologically relevant.

  How PLIP uses BioLiP BioLiP home page

Disclaimer and Commercial Use

The Protein-Ligand Interaction Profiler (PLIP) web service is provided free of charge to the academic community and non-profit organizations in good faith without guarantees of any kind. For more information about options for commercial usage, please contact Michael Schroeder.